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| Rockerok | Дата: Понедельник, 15 Июня 2009, 15:57 | Сообщение # 1 |
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Группа: Администраторы
Сообщений: 65535
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| Итак, ярким примеров является Уссурочка!
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| tcsindustryx | Дата: Пятница, 24 Апреля 2015, 01:21 | Сообщение # 61 |
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Группа: Гости
| Vancomycin INN /v??k??ma?s?n/ is a glycopeptide antibiotic acquainted with in the prophylaxis and treatment of infections caused next to Gram-positive bacteria. Vancomycin was key secluded in 1953 at Eli Lilly, from a begrime representation tranquil from the upland jungles of Borneo by a missionary. It is a inherently occurring antibiotic made past the tarnish bacterium Actinobacteria species Amycolatopsis orientalis(formerly designated Nocardia orientalis). It is a complex chemical compound and an warning of a comparatively rare haloorganic above compound, containing two covalently bonded chlorine atoms.
The compound was industrially produced alongside fermentation and accepted the generic label vancomycin, derived from the term "vanquish." The native sign for vancomycin was by reason of the treatment ofpenicillin-resistant Staphylococcus aureus, a avail oneself of kept astir in behalf of uncountable years beside the occurrence that formulate had to be given intravenously and thus provided bacteria fewer opportunities to evolve freedom fighters, and the in truth that organisms were extent perceptible to evolve to modify to it, orderly in experiments.
As regards various years since its initial demand, vancomycin had traditionally been unsocial as a psychedelic of "mould remedy have recourse to" due to cock's-crow observations of its nephrotoxicity and ototoxicity as artistically as its intravenous dosing requirements.[1 - Recently, however, vancomycin unaffected organisms are attractive common. As a consequence, vancomycin is increasingly being displaced from this role during newer antibiotics such as linezolid(Zyvox), daptomycin (Cubicin), and quinupristin/dalfopristin (Synercid).
Recapitulation
Vancomycin was primary cloistered in 1953 during Edmund Kornfeld (working at Eli Lilly) from a refuse sample unruffled from the private jungles of Borneo by a missionary.[2 - The organism that produced it was in the final analysis named Amycolatopsis orientalis.[3 - The earliest clue for vancomycin was in search the treatment of penicillin-resistant Staphylococcus aureus.[3 - [4 -
The compound was initially called concoct 05865, but was eventually assumption the generic namevancomycin, derived from the length of time "vanquish".[3 - One gain that was apace apparent is that staphylococci did not bare critical guerillas ignoring serial thoroughfare in customs media containing vancomycin. The rapid development of penicillin resistance by means of staphylococci led to the compound's being fast-tracked on approval by the Rations and Drug Delivery (FDA) in 1958. Eli Lilly first marketed vancomycin hydrochloride under the trade label Vancocin[4 - and as COVANC from Pith, India.[citation needed -
Vancomycin on no account became the first-line treatment for the treatment of Staphylococcus aureus fitted certain reasons:
1. It possesses slipshod viva voce bioavailability; it sine qua non be specified intravenously as a service to most infections.
2. β-Lactamase-resistant semi-synthetic penicillins such as methicillin (and its successors,nafcillin and cloxacillin) were subsequently developed, which bear bettor activity against non-MRSA staphylococci.
3. Inopportune trials tolerant of at the crack judaism tref forms of vancomycin ("Mississippi mud"), which were originate to be toxic to the ears and to the kidneys;[5 - these findings led to vancomycin's being relegated to the emplacement of a anaesthetize of model resort.[4 -
In 2004, Eli Lilly licensed Vancocin to ViroPharma in the U.S., Flynn Pharma in the UK, and Aspen Pharmacare in Australia. The obvious expired in the at the crack 1980s; the FDA authorized the traffic of several generic versions in the USA, including from manufacturers Bioniche Pharma, Baxter Healthcare, Sandoz, Akorn Strides and Hospira.[6 -
An uttered ceremony of vancomycin was initially approved by the FDA in 1986 with a view the treatment of Clostridium difficile induced pseudomembranous colitis. It is not orally absorbed into the blood and remains in the gastrointestinal tract to eradicate C. difficile. This commodity is currently marketed by ViroPharmain the USA.[7 -
From http://www.tcsindustry.com - TCS INDUSTRY LTD
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| fmyykjr | Дата: Суббота, 25 Апреля 2015, 14:41 | Сообщение # 62 |
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Группа: Гости
| Vancomycin INN /v??k??ma?s?n/ is a glycopeptide antibiotic used in the prophylaxis and treatment of infections caused by Gram-positive bacteria. Vancomycin was maiden eremitical in 1953 at Eli Lilly, from a soil sample tranquil from the personal jungles of Borneo by a missionary. It is a as a consequence occurring antibiotic made by the tarnish bacterium Actinobacteria species Amycolatopsis orientalis(once upon a time designated Nocardia orientalis). It is a complex chemical mix and an example of a comparatively rare haloorganic above compound, containing two covalently bonded chlorine atoms.
The unite was industrially produced at near fermentation and accepted the generic honour vancomycin, derived from the call "vanquish." The native sign seeing that vancomycin was by reason of the treatment ofpenicillin-resistant Staphylococcus aureus, a smoke kept aware in behalf of varied years beside the low-down that compound had to be accustomed intravenously and as follows provided bacteria fewer opportunities to evolve resistance, and the happening that organisms were extent boeotian to evolve to adapt to it, regular in experiments.
As regards many years since its prime consume, vancomycin had traditionally been distant as a painkiller of "mould remedy have recourse to" straight membership fee to premature observations of its nephrotoxicity and ototoxicity as artistically as its intravenous dosing requirements.[1 - Recently, to whatever manner, vancomycin resistant organisms are befitting common. As a consequence, vancomycin is increasingly being displaced from this function on newer antibiotics such as linezolid(Zyvox), daptomycin (Cubicin), and quinupristin/dalfopristin (Synercid).
Intelligence
Vancomycin was first secluded in 1953 not later than Edmund Kornfeld (working at Eli Lilly) from a refuse experience collected from the private jungles of Borneo not later than a missionary.[2 - The organism that produced it was when all is said named Amycolatopsis orientalis.[3 - The case indication for vancomycin was for the sake of the treatment of penicillin-resistant Staphylococcus aureus.[3 - [4 -
The compound was initially called parathesis 05865, but was finally the truth the generic namevancomycin, derived from the span of time "vanquish".[3 - A person benefit that was quickly discernible is that staphylococci did not emerge significant resistance undeterred by serial thoroughfare in culture media containing vancomycin. The alacritous development of penicillin partisans by way of staphylococci led to the heighten's being fast-tracked exchange for endorsement about the Foodstuffs and Drug Administration (FDA) in 1958. Eli Lilly basic marketed vancomycin hydrochloride controlled by the trade name Vancocin[4 - and as COVANC from Nub, India.[citation needed -
Vancomycin on no account became the first-line treatment for the treatment of Staphylococcus aureus for a variety of reasons:
1. It possesses insolvent viva voce bioavailability; it ought to be conceded intravenously for most infections.
2. β-Lactamase-resistant semi-synthetic penicillins such as methicillin (and its successors,nafcillin and cloxacillin) were later on developed, which sooner a be wearing better action against non-MRSA staphylococci.
3. Ahead of time trials cast-off initial promiscuous forms of vancomycin ("Mississippi mud"), which were originate to be toxic to the ears and to the kidneys;[5 - these findings led to vancomycin's being relegated to the leaning of a psychedelic of last resort.[4 -
In 2004, Eli Lilly licensed Vancocin to ViroPharma in the U.S., Flynn Pharma in the UK, and Aspen Pharmacare in Australia. The obvious expired in the initially 1980s; the FDA authorized the traffic of distinct generic versions in the USA, including from manufacturers Bioniche Pharma, Baxter Healthcare, Sandoz, Akorn Strides and Hospira.[6 -
An vocal ceremony of vancomycin was from the outset approved not later than the FDA in 1986 with a view the treatment of Clostridium difficile induced pseudomembranous colitis. It is not orally absorbed into the blood and remains in the gastrointestinal essay to eradicate C. difficile. This product is currently marketed by means of ViroPharmain the USA.[7 -
From http://www.fmyykj.com - suzhou pharmaceutical technology co.,ltd.
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| Mister | Дата: Пятница, 15 Мая 2015, 19:53 | Сообщение # 63 |
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Группа: Гости
| Привет, котики! Чмоки в щеки! Сто лет вас не видел. Пишите, чо  mikevister@gmail.comДобавлено (15 Май 2015, 19:53)
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Админ, ипона мама, почисти форум от говна. Или admin has been banned by Barmen и спит лицом в салате?
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| fmyykja | Дата: Вторник, 29 Декабря 2015, 08:28 | Сообщение # 64 |
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Группа: Гости
| Moxidectin (Milbemycin B[1 - ) kills parasites, so is used instead of the mitigation and manage of heartworm and intestinal worms, and can be originate in treatments prescribed in place of animals such as dogs, cats, horses, livestock and sheep. Diligence methods an eye to moxidectin diversify sooner than treatment, and group oral, current, and injectable solutions. Cydectin Spurt On is a barter baptize as a replacement for a formulation in compensation from on cows and red deer.
Moxidectin is a semisynthetic imitative of nemadectin [2 - which is produced past fermentation before Streptomyces cyano-griseus. This Streptomyces species was discovered in a turf specimen from Australia in the past due 1980s unruffled alongside an agronomist working destined for the American Cyanamid company.
Moxidectin treats and controls some of the most common internal and external parasites by way of selectively binding to parasites’ glutamate-gated chloride ion channels. These channels are needed to the go of invertebrate fortitude and muscle cells; when moxidectin binds to the channels, it disrupts neurotransmission, resulting in paralysis and death of the parasite.
Studies of moxidectin demonstrate the side effects change at near animalistic and may be fake through the upshot’s formulation, assiduity method and dosage. The products are mainly recommended around a veterinarian to ensure counterbalance avail oneself of and application. Herding dogs may be avermectin-sensitive, but avermectin-sensitive dogs can tolerate measure doses after heartworm prevention. Moxidectin is manifestly harmless for collie breeds. As a heartworm preventative, moxidectin can be injected in a wink every six months covered by the make big cheese Proheart6, or every 12 months lower than drunk the brand name prominence Proheart SR 12.
Moxidectin is the rationale of a irritant to assess its suitability, as an alternative to ivermectin, to conduct towards onchocerciasis in humans.[3 -
From http://www.fmyykj.com - suzhou pharmaceutical technology co.,ltd.
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| lenorepg60 | Дата: Пятница, 15 Января 2016, 08:56 | Сообщение # 65 |
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Группа: Гости
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| famuyiyaoh | Дата: Среда, 20 Января 2016, 07:15 | Сообщение # 66 |
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Группа: Гости
| Moxidectin (Milbemycin B[1 - ) kills parasites, so is used because of the mitigation and supervise of heartworm and intestinal worms, and can be organize in treatments prescribed for animals such as dogs, cats, horses, cattle and sheep. Relevancy methods in the service of moxidectin alternate by treatment, and register vocalized, timely, and injectable solutions. Cydectin Flow On is a barter baptize towards a formulation for urgency on beef and red deer.
Moxidectin is a semisynthetic imitative of nemadectin [2 - which is produced by fermentation before Streptomyces cyano-griseus. This Streptomyces species was discovered in a turf sample from Australia in the past due 1980s at ease during an agronomist working in the direction of the American Cyanamid company.
Moxidectin treats and controls some of the most unrefined internal and outward parasites on selectively binding to parasites’ glutamate-gated chloride ion channels. These channels are vital to the r搇e of invertebrate balls and muscle cells; when moxidectin binds to the channels, it disrupts neurotransmission, resulting in paralysis and cessation of the parasite.
Studies of moxidectin demonstrate the side effects remodel at near rude and may be false beside the upshot’s formulation, appositeness method and dosage. The products are mainly recommended about a veterinarian to insure counterbalance speak and application. Herding dogs may be avermectin-sensitive, but avermectin-sensitive dogs can admit standard doses after heartworm prevention. Moxidectin is evidently harmless in regard to collie breeds. As a heartworm preventative, moxidectin can be injected at one time every six months at the beck the brand rating Proheart6, or every 12 months answerable to the brand eminence Proheart SR 12.
Moxidectin is the rationale of a effort to assess its suitability, as an another to ivermectin, to treat onchocerciasis in humans.[3 -
From http://www.fmyykj.com - suzhou pharmaceutical technology co.,ltd.
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| Гость | Дата: Четверг, 14 Апреля 2016, 15:22 | Сообщение # 67 |
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Группа: Гости
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| tcsgroupw | Дата: Пятница, 01 Июля 2016, 21:14 | Сообщение # 68 |
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Группа: Гости
| Docetaxel (as generic or subservient to the trade name Taxotere) is a clinically set anti-mitotic chemotherapy medication (medication which interferes with stall department). It is hand-me-down mostly for the treatment of breast, ovarian, prostate, and non-small room lung cancer.[1 - [2 - [3 - Docetaxel has an FDA approved be entitled to after treatment of patients who partake of locally advanced, or metastatic titty or non small-cell lung cancer who partake of undergone anthracycline-based chemotherapy and failed to stop cancer advance or relapsed[4 - and a European approval to exploit in hormone-refractory prostate cancer.[5 -
According to a 2005 article in the magazine Drugs, docetaxel administered as a one-hour infusion every three weeks as a rule as surplus a ten cycle track, docetaxel is considered as or more compelling than doxorubicin, paclitaxel and fluorouracil as a cytotoxic agent.[1 - Extent the effectiveness of docetaxel versus paclitaxel and other taxanes is quiescent controversial. A variety of more recent articles be suffering with build "no confirmation that regimens containing docetaxel cry quits greater benefits than those including paclitaxel."[6 - Additionally, the optimal scheduling of docetaxel and other taxanes remains unconfirmed. A three-week distribution list old to be and is at rest considered efficient but chic studies are indicating a weekly register might be better. A 2010 article in On the qui vive Clinical Pharmacology states, "weekly charge has emerged as the optimal schedule." Docetaxel is marketed worldwide under the honour Taxotere during Sanofi-Aventis.[7 - Annual sales in 2010 were Euro 2.122 billion ($US 3.1 billion). The transparent expired in 2010.[citation
Constitution
Docetaxel is of the chemotherapy drug bearing; taxane, and is a semi-synthetic analogue of paclitaxel (Taxol), an draw forth from the bark of the rare Pacific yew tree Taxus brevifolia.[2 - Owed to dearth of paclitaxel, international study was carried peripheral exhausted foremost to the formulation of docetaxel – an esterified output of 10-deacetyl baccatin III, which is extracted from the renewable and readily present European yew tree.
Docetaxel differs from paclitaxel at two positions in its chemical structure. It has a hydroxyl working coterie on carbon 10, whereas paclitaxel has an acetate ester, and a tert-butyl carbamate ester exists on the phenylpropionate side gyve instead of the benzyl amide in paclitaxel. The carbon 10 practical organize change causes docetaxel to be more water soluble than paclitaxel.[2 -
Formulations and compositions
Docetaxel is a pure coat capacity and is the active ingredient convenient in 20 mg and 80 mg Taxotere single-dose vials of concentrated anhydrous docetaxel in polysorbate 80.[2 - [8 - The answer is a discerning brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL.[8 - 20 mg Taxotere is distributed in a blister carton containing one single-dose vial of Taxotere (docetaxel) preparation in 0.5 mL disinfected pyrogen-free anhydrous polysorbate 80, and a single amount Taxotere reliable vial containing 1.5 mL 13% ethanol in saline to be combined and diluted in a 250 mL infusion evening bag containing 0.9% sodium chloride or 5% glucose in the interest administration.[8 - 80 mg Taxotere is supplied identically but with 2.0 mL polysorbate 80 and 6.0 mL 13% ethanol in saline. The docetaxel and reliable vials are combined to provide a unravelling of 10 mg/mL and the required portion is haggard from this solution. Vials have an overfill to compensate in compensation fluid harm during preparation, foaming, adhesion to vial walls and the dead volume. 20 mg vials may be stored for 24 months here 25 °C away from insight and 80 mg vials respecting 26 months in the nevertheless conditions.[8 -
Recently Sanofi has got approval because of one-vial formulation.[citation needed - With this one-vial formulation, the preparation of the infusion solution is simplified nearby eliminating the first dilution step. The two-vial and one-vial formulations carry the unchanged panacea theme, docetaxel trihydrate, and the word-for-word excipients (ethanol, polysorbate 80 and citric acid). The one-vial formulation is administered as an aqueous intravenous settling that contains the same drug burden in the after all is said concentration as the already approved two-vial formulation. The unvarying grade, status, and quantity of polysorbate 80 are closest in the infusion explication of both formulations. The only difference between these two formulations is the volume of ethanol.
From http://www.tcsindustry.com - TCS INDUSTRY LTD
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